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Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL)

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SRRF; HNRNPLL; BLOCK24; Stromal RNA-regulating factor

Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL)
CCC N209
HGNC 25127
MGI 1919942
PubMed 23934048
RGD 1305861
UniProt Q8WVV9
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC), a tyrosine phosphatase essential for T-cell development and activation.
The HNRNPLL A isoform contains a third RRM domain and PTB, SH2, and WW interaction motifs. The HNRNPLL B isoform contains a coiled-coil region, a DNA binding domain, and 14-3-3 and PDZ interaction motifs. The HNRNPLL isoforms share 69% amino acid homology with HNRNPL and 46% homology with HNRNPI and ROD1 proteins. RT-PCR analysis detected expression of HNRNPLL transcripts A and B in bone marrow stromal cells only. Additional transcripts that differed in the 5-prime and 3-prime untranslated region were identified by database analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L Like Protein (HNRPLL) ELISA Kit Customized Service Offer
  1. "Alternatively spliced isoforms of a novel stromal RNA regulating factor."Gene 334:113-121(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL."Science 321:686-691(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]