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Prune Homolog 2 (PRUNE2)

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BMCC1; BNIPXL; C9orf65; BNIP2 motif-containing molecule at the C-terminal region 1

Prune Homolog 2 (PRUNE2)
CCC N196
HGNC 25209
MGI 1925004
PubMed 12168954
RGD 1311350
UniProt Q8WUY3
Wiki PRUNE2
The deduced 2,714-amino acid protein has a coiled-coil sequence, a proline-rich region, a P loop, and a C-terminal BNIP2 and CDC42GAP (ARHGAP1) homology (BCH) domain, which contains 3 putative transmembrane domains. Northern blot analysis detected a 12-kb transcript in fetal brain. Semiquantitative RT-PCR revealed BMCC1 expression in all tissues examined except bone marrow, thymus, and spleen.
Expression was highest in brain, cerebellum, spinal cord, and adrenal gland. RT-PCR of synchronized HeLa cells showed that BMCC1 was predominantly expressed in G1 phase of the cell cycle. In situ hybridization of mouse embryos showed that Bmcc1 was specifically expressed in neural tube and neural crest-related tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog 2 (PRUNE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog 2 (PRUNE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog 2 (PRUNE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog 2 (PRUNE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog 2 (PRUNE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog 2 (PRUNE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog 2 (PRUNE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog 2 (PRUNE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog 2 (PRUNE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog 2 (PRUNE2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog 2 (PRUNE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog 2 (PRUNE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog 2 (PRUNE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog 2 (PRUNE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog 2 (PRUNE2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas."Oncogene 25:1931-1942(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer."Prostate 70:70-78(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]