Melanoma Antigen Family B10 (MAGEB10)

By searching databases for sequences similar to MAGED2, Chomez et al. (2001) identified MAGEB10. The deduced protein contains the characteristic MAGE domain of about 200 amino acids. RT-PCR detected MAGEB10 expression in testis, but not in other normal tissues examined.By genomic sequence analysis, Chomez et al. (2001) mapped the MAGEB gene cluster to chromosome Xp22.2-p21.2.

MAGED2 contains a segment in its central region that is homologous to the 200-amino acid MAGE segment at the C terminus of other MAGE proteins. RT-PCR analysis demonstrated that, unlike the testis- and tumor-specific expression of many MAGE genes, MAGED2 is expressed ubiquitously in normal human tissues and in most, if not all, cell types.