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Lin-54 Homolog (LIN54)

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MIP120; CXCDC1; CXC Domain Containing 1

Lin-54 Homolog (LIN54)
CCC N184
HGNC 25397
MGI 2140902
PubMed 19725879
UniProt Q6MZP7
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes . The deduced 749-amino acid protein contains 2 cysteine-rich C-terminal CxC domains separated by a short spacer. SDS-PAGE of MOLT-4 cells and Western blot analysis of HeLa cells detected LIN54 at an apparent molecular mass of 110 kD.Domain analysis revealed that the C-terminal helix-coil-helix region of LIN54 was essential for its binding to p130 (RBL2) and BMYB.
The CxC domain of LIN54 was identified as a DNA-binding domain that could bind the promoter region of the CDC2 gene in a sequence-specific manner. LIN54 bound 2 regions in the CDC2 promoter, 1 of which overlaps with the cell cycle homology region at the transcription start site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-54 Homolog (LIN54) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-54 Homolog (LIN54) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-54 Homolog (LIN54) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-54 Homolog (LIN54) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-54 Homolog (LIN54) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-54 Homolog (LIN54) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-54 Homolog (LIN54) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-54 Homolog (LIN54) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-54 Homolog (LIN54) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-54 Homolog (LIN54) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner."FEBS J. 276:5703-5716(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]