≡

Spindle Assembly 6 Homolog (SASS6)

[Edit]

SAS6

Spindle Assembly 6 Homolog (SASS6)
CCC N183
HGNC 25403
MGI 1920026
PubMed 14654843
RGD 1306255
UniProt Q6UVJ0
Wiki SASS6
SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle.
SAS6 associated only transiently with nascent procentrioles, whereas CEP135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. SAS6 was necessary for procentriole formation in human cell lines, and that SAS6 localized asymmetrically next to the centriole at the onset of procentriole formation, prior to the recruitment of CETN2. SAS6 levels oscillated during the cell cycle; it was degraded in mitosis starting at anaphase, and it accumulated again at the end of the following G1 phase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle Assembly 6 Homolog (SASS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle Assembly 6 Homolog (SASS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle Assembly 6 Homolog (SASS6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle Assembly 6 Homolog (SASS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle Assembly 6 Homolog (SASS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle Assembly 6 Homolog (SASS6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle Assembly 6 Homolog (SASS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle Assembly 6 Homolog (SASS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle Assembly 6 Homolog (SASS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle Assembly 6 Homolog (SASS6) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Centriole assembly requires both centriolar and pericentriolar material proteins."Dev. Cell 7:815-829(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells."Nat. Cell Biol. 7:115-125(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The Polo kinase Plk4 functions in centriole duplication."Nat. Cell Biol. 7:1140-1146(2005) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Plk4-induced centriole biogenesis in human cells."Dev. Cell 13:190-202(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Role of CAP350 in centriolar tubule stability and centriole assembly."PLoS ONE 3:E3855-E3855(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."Nat. Cell Biol. 13:1004-1009(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Structures of SAS-6 suggest its organization in centrioles."Science 331:1196-1199(2011) [PubMed] [Europe PMC] [Abstract]