≡

ADP Ribosylation Factor Like Protein 13B (ARL13B)

[Edit]

ARL2L1; JBTS8; ADP-Ribosylation Factor-Like 2-Like 1

ADP Ribosylation Factor Like Protein 13B (ARL13B)
CCC N180
HGNC 25419
MGI 1915396
PubMed 23223633
RGD 1584979
UniProt Q3SXY8
Wiki ARL13B
In the process of positional cloning of the gene responsible for Bardet-Biedl syndrome type 3 (BBS3), which has been mapped to 3p12-q13 by linkage analysis, Fan et al. (2004) determined that the C. elegans ARL2L1 ortholog is expressed in ciliated cells. They found no mutations in ARL2L1 in families with BBS3.
In mouse tissues, Arl13b protein was expressed in cilia of all organs examined, including developing cerebellum, distal renal collecting ducts, and the retinal photoreceptor cilia layer connecting the inner and outer segments. About 40% of cilia-like structures in cerebellum showed ARL13B expression at embryonic day 16, compared with 1% of cells by postnatal day 21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 13B (ARL13B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 13B (ARL13B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 13B (ARL13B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 13B (ARL13B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 13B (ARL13B) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome."Nat. Genet. 36:989-993(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation."Biochem. Biophys. Res. Commun. 373:119-124(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Pitchfork regulates primary cilia disassembly and left-right asymmetry."Dev. Cell 19:66-77(2010) [PubMed] [Europe PMC] [Abstract]
  7. "SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors."J. Cell Biol. 199:589-598(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Active transport and diffusion barriers restrict Joubert syndrome-associated ARL13B/ARL-13 to an inv-like ciliary membrane subdomain." PLoS Genet. 9:E1003977-E1003977(2013) [PubMed] [Europe PMC] [Abstract]
  9. "ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting."Proc. Natl. Acad. Sci. U.S.A. 109:19691-19696(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Arl13b regulates endocytic recycling traffic."Proc. Natl. Acad. Sci. U.S.A. 109:21354-21359(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division."Cell 155:333-344(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome." Am. J. Hum. Genet. 83:170-179(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy."J. Med. Genet. 48:105-116(2011) [PubMed] [Europe PMC] [Abstract]