≡

RNA Binding Motif Protein 22 (RBM22)

[Edit]

ZC3H16; fSAP47; Cwc2; Functional Spliceosome-Associated Protein 47; Zinc finger CCCH domain-containing protein 16; Pre-mRNA-splicing factor RBM22

RNA Binding Motif Protein 22 (RBM22)
CCC N170
HGNC 25503
MGI 1914060
PubMed 8681136
RGD 1305770
UniProt Q9NW64
Wiki RBM22
Using ALG2 as bait in a yeast 2-hybrid screen of a human peripheral blood cDNA library, Montaville et al. (2006) cloned RBM22. The deduced 420-amino acid protein contains a conserved zinc finger of the type Cx8Cx5Cx3H, followed by an RNA-binding domain. The mouse and human RBM22 proteins are identical. Fluorescence-tagged RBM22 localized to the nucleus of transfected mouse fibroblasts.
Knockdown of RBM22 in HeLa cells resulted in mitotic arrest and a cytokinesis defect, but not cell death.Montaville et al. (2006) found that fluorescence-tagged human RBM22 redirected fluorescence-tagged ALG2 from the cytoplasm to the nucleus following coexpression in mouse fibroblasts and zebrafish embryos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 22 (RBM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 22 (RBM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 22 (RBM22) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 22 (RBM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 22 (RBM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 22 (RBM22) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 22 (RBM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 22 (RBM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 22 (RBM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 22 (RBM22) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transcriptional map of the Treacher Collins candidate gene region."Genome Res. 6:26-34(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22."Biochim. Biophys. Acta 1763:1335-1343(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The influence of calcium signaling on the regulation of alternative splicing."Biochim. Biophys. Acta 1793:979-984(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7."Biochim. Biophys. Acta 1813:1045-1049(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre."EMBO J. 31:1591-1604(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of RNA binding domain in pre-mRNA-splicing factor RBM22."Submitted (OCT-2007) to the PDB data bank