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Vac14 Homolog (VAC14)

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TAX1BP2; ArPIKfyve; TRX; Tax1(T-Cell Leukemia Virus Type I)Binding Protein 2

Vac14 Homolog (VAC14)
CCC N169
HGNC 25507
MGI 2157980
PubMed 12719380
UniProt Q08AM6
Wiki ArPIKFYVE
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE and the PtdIns(3,5)P2 phosphatase FIG4 . VAC14 functions as an activator of PIKFYVE. The deduced 221-amino acid TRX protein is predominantly hydrophilic in its C-terminal region. Northern blot analysis of human tissues detected a major 3.5-kb TRX transcript in all tissues examined, namely brain, heart, lung, liver, pancreas, kidney, skeletal muscle, and placenta. However, Western blot analysis detected TRX expression only in lymphocytes and lymphocytic-derived cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vac14 Homolog (VAC14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vac14 Homolog (VAC14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vac14 Homolog (VAC14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vac14 Homolog (VAC14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vac14 Homolog (VAC14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vac14 Homolog (VAC14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vac14 Homolog (VAC14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vac14 Homolog (VAC14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vac14 Homolog (VAC14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vac14 Homolog (VAC14) ELISA Kit Customized Service Offer
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