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WD Repeat Containing Protein, Antisense To TP53 (WRAP53)

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WDR79; TCAB1; WD Repeat Domain 79; Telomerase Cajal Body Protein 1; WD40 repeat-containing protein antisense to TP53 gene

WD Repeat Containing Protein, Antisense To TP53 (WRAP53)
CCC N167
HGNC 25522
MGI 2384933
PubMed 19250907
RGD 1359624
UniProt Q9BUR4
Immunoprecipitation showed that TCAB1 interacted specifically with dyskerin, TERT, and TERC, all principal components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. Immunoprecipitation and immunofluorescence experiments showed that TCAB1 is a holoenzyme subunit that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function.
Depletion of TCAB1 by RNA interference prevented TERC from associating with Cajal bodies, disrupted telomerase-telomere association, and abrogated telomere synthesis by telomerase. Thus, TCAB1 controls telomerase trafficking and is required for telomere synthesis in human cancer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Protein, Antisense To TP53 (WRAP53) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Protein, Antisense To TP53 (WRAP53) ELISA Kit Customized Service Offer
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  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage."Mol. Cell 33:462-471(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita."Genes Dev. 25:11-16(2011) [PubMed] [Europe PMC] [Abstract]