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Centrosomal Protein 27kDa (CEP27)

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HAUS2; C15orf25; HAUS Augmin Like Complex Subunit 2

Centrosomal Protein 27kDa (CEP27)
CCC N164
HGNC 25530
MGI 1913546
PubMed 23456457
RGD 1587133
UniProt Q9NVX0
HAUS2 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly. CEP27 is a critical component of the human augmin complex, and they confirmed interaction of CEP27 with the other 7 augmin subunits by coimmunoprecipitation analysis. Knockdown of CEP27 or any of the other augmin subunits resulted in destabilization of kinetochore microtubules, formation of multipolar spindles, fragmentation of centrosomes, and increased centrosome size.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 27kDa (CEP27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 27kDa (CEP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 27kDa (CEP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 27kDa (CEP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 27kDa (CEP27) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 27kDa (CEP27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 27kDa (CEP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 27kDa (CEP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 27kDa (CEP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 27kDa (CEP27) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 27kDa (CEP27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 27kDa (CEP27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 27kDa (CEP27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 27kDa (CEP27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 27kDa (CEP27) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  5. "HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity."Curr. Biol. 19:816-826(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]