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Amplified In Breast Cancer 2 (ABC2)

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SMG8; C17orf71

Amplified In Breast Cancer 2 (ABC2)
CCC N159
HGNC 25551
MGI 1921383
RGD 1306862
UniProt Q8ND04
The kinase SMG1 forms a surveillance complex with UPF1 (RENT1), ERF1 (ETF1), and ERF3 (GSPT1) on spliced mRNAs during recognition of premature termination codons. If an exon junction complex (EJC) exists downstream from the surveillance complex, SMG1 phosphorylates UPF1, and this step is rate limiting for NMD. Both SMG8 and SMG9 suppressed the kinase activity of SMG1, and both were SMG1 target substrates.
Depletion of SMG9 resulted in accumulation of phosphorylated UPF1. SMG8 was required to recruit SMG1 to the surveillance complex, and depletion of SMG8 caused accumulation of a complex containing the ribosome, UPF1, ERF1, ERF3, and the EJC on the spliced mRNA-protein complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amplified In Breast Cancer 2 (ABC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amplified In Breast Cancer 2 (ABC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amplified In Breast Cancer 2 (ABC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amplified In Breast Cancer 2 (ABC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amplified In Breast Cancer 2 (ABC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amplified In Breast Cancer 2 (ABC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amplified In Breast Cancer 2 (ABC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amplified In Breast Cancer 2 (ABC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amplified In Breast Cancer 2 (ABC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amplified In Breast Cancer 2 (ABC2) ELISA Kit Customized Service Offer
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  9. "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8."Genes Dev. 25:153-164(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex."Nucleic Acids Res. 39:347-358(2011) [PubMed] [Europe PMC] [Abstract]
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  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]