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Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6)

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MYOGEF; Myosin-interacting guanine nucleotide exchange factor

Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6)
CCC N157
HGNC 25562
MGI 2682298
PubMed 19421144
UniProt Q3KR16
MyoGEF interacts directly with nonmuscle myosin II and showed that MyoGEF activates RhoA and induces formation of myosin filaments. Both MyoGEF and myosin II colocalize to the cleavage furrow of early anaphase cells. Disruption of MyoGEF expression by RNAi resulted in the formation of multinucleated cells.
The N-terminal domain of ezrin binds to a C-terminal region of PLEKHG6. PLEKHG6 exhibited preferential GEF activity toward RhoG , which may be its primary target. PLEKHG6 occurs in a complex with ezrin, RhoG, and the RhoG effector ELMO. PLEKHG6, together with ezrin, induced ruffles at the cell membrane, and both were necessary for macropinocytosis to occur.The deduced protein showed highest sequence identity with GEF720 (PLEKHG5).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family G, Member 6 (PLEKHG6) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis."Cell Cycle 5:1234-1239(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells."Mol. Biol. Cell 18:4780-4793(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle."Mol. Biol. Cell 20:1428-1440(2009) [PubMed] [Europe PMC] [Abstract]