≡

Ribonuclease H2 Subunit B (RNASEH2B)

[Edit]

DLEU8; AGS2; Deleted In Lymphocytic Leukemia 8; Aicardi-Goutieres Syndrome 2; Ribonuclease HI subunit B

Ribonuclease H2 Subunit B (RNASEH2B)
CCC N148
HGNC 25671
MGI 1914403
PubMed 19015152
RGD 1359710
UniProt Q5TBB1
Wiki RNASEH2B
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
By genomewide linkage analysis of 10 families with Aicardi-Goutieres syndrome in whom linkage to AGS1 was excluded, Ali et al. (2006) identified a putative disease locus, termed AGS2, on chromosome 13q14-q21 (maximum multipoint lod score of 5.75 at marker D13S768). The AGS2 locus lies within a 4.7-cM region between D13S284 and D13S1309.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease H2 Subunit B (RNASEH2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease H2 Subunit B (RNASEH2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease H2 Subunit B (RNASEH2B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease H2 Subunit B (RNASEH2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease H2 Subunit B (RNASEH2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease H2 Subunit B (RNASEH2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease H2 Subunit B (RNASEH2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease H2 Subunit B (RNASEH2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease H2 Subunit B (RNASEH2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease H2 Subunit B (RNASEH2B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects."J. Biol. Chem. 286:10540-10550(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection." Nat. Genet. 38:910-916(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Clinical and molecular phenotype of Aicardi-Goutieres syndrome." Am. J. Hum. Genet. 81:713-725(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome." Arthritis Rheum. 62:1469-1477(2010) [PubMed] [Europe PMC] [Abstract]