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TBC1 Domain Family, Member 15 (TBC1D15)

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Rab7-GAP; GTPase-activating protein RAB7

TBC1 Domain Family, Member 15 (TBC1D15)
CCC N145
HGNC 25694
MGI 1913937
PubMed 23468968
RGD 1307920
UniProt Q8TC07
Wiki TBC1D15
Tbc1d15 increased Rab7 GTPase activity and showed a lower rate of increase in activity for Rab11, but was largely inactive against Rab4 and Rab6 (RAB6A).
The deduced 691-amino acid human protein shares 88% amino acid identity with its mouse homolog, and both proteins contain the TBC domain . TBC1D15 shares 46% identity with TBC1D17. Northern blot analysis of mouse tissues detected 2 variants in most tissues examined, with highest expression in heart, liver, and testis and lower expression in brain, spleen, lung, kidney, and skeletal muscle. Immunofluorescence studies showed a diffuse intracellular distribution of Tbc1d15 in transfected COS-1 cells, suggesting primarily cytosolic localization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 15 (TBC1D15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 15 (TBC1D15) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 15 (TBC1D15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 15 (TBC1D15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 15 (TBC1D15) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 15 (TBC1D15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 15 (TBC1D15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 15 (TBC1D15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 15 (TBC1D15) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 15 (TBC1D15) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]