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Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2)

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HSD38

Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2)
CCC N135
HGNC 25745
MGI 2140076
RGD 1565346
UniProt Q9H9L3
Truncation experiments demonstrated that the C terminus of ISG20L2 was sufficient to produce nucleolar localization. GST/ISG20L2 fusion experiments confirmed that the purified protein possessed 3-prime to 5-prime exoribonuclease activity. Coimmunoprecipitation studies showed that ISG20L2 associated with several ribosomal proteins through its N terminus. When overexpressed, ISG20L2 caused a specific decrease in 12S precursor rRNA and, conversely, an increase when it was silenced.
The deduced 353-amino acid protein, designated ISG20L2, has a predicted exonuclease domain between amino acids 178 and 344. In S. cerevisiae, Rex4 is involved in ribosome biogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Stimulated Exonuclease Gene 20kDa Like Protein 2 (ISG20L2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  5. "ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis."Mol. Cell. Proteomics 7:546-559(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]