≡

HAUS Augmin Like Complex Subunit 6 (HAUS6)

[Edit]

FAM29A; Dgt6; Family With Sequence Similarity 29 Member A

HAUS Augmin Like Complex Subunit 6 (HAUS6)
CCC N128
HGNC 25948
MGI 1923389
UniProt Q7Z4H7
HAUS6 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly.
FAM29A interacted with PLK1 in HeLa cells. FAM29A also associated with kinetochore microtubules during mitosis. Depletion of FAM29A reduced the spindle microtubule density, including that of kinetochore microtubules, weakened the microtubule-kinetochore attachment, and activated the spindle checkpoint.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HAUS Augmin Like Complex Subunit 6 (HAUS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HAUS Augmin Like Complex Subunit 6 (HAUS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HAUS Augmin Like Complex Subunit 6 (HAUS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 6 (HAUS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 6 (HAUS6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HAUS Augmin Like Complex Subunit 6 (HAUS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HAUS Augmin Like Complex Subunit 6 (HAUS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HAUS Augmin Like Complex Subunit 6 (HAUS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 6 (HAUS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 6 (HAUS6) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle."J. Cell Biol. 181:421-429(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle."J. Cell Biol. 183:835-848(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity."Curr. Biol. 19:816-826(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]