SID1 Transmembrane Family, Member 1 (SIDT1)

Double-stranded RNA (dsRNA)-mediated gene interference (RNAi) occurs systemically in C. elegans. Injection of gene-specific dsRNA into 1 tissue leads to the posttranscriptional silencing of that gene in other tissues and in the worm's progeny. SIDT1 has 827 amino acids and 11 transmembrane domains. no homolog was detectable in Drosophila and suggested that the presence of SID1 in mammals indicates that RNAi may be systemic in these species.SID1 is a multispan transmembrane protein that sensitizes Drosophila cells to soaking RNAi with a potency that is dependent on double-stranded RNA (dsRNA) length. Further analyses revealed that SID1 enables passive cellular uptake of dsRNA. systemic RNAi in C. elegans involves SID1-mediated intercellular transport of dsRNA.