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Membrane Associated Ring Finger Protein 5 (MARCH5)

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MARCH-V; RNF153; MITOL; Ring Finger Protein 153; Mitochondrial ubiquitin ligase; RING finger protein 153; E3 ubiquitin-protein ligase MARCH5

Membrane Associated Ring Finger Protein 5 (MARCH5)
CCC N123
HGNC 26025
MGI 1915207
PubMed 20103533
RGD 1305617
UniProt Q9NX47
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2) and DRP1 (DNM1L).
Immunofluorescence studies showed that overexpression of MARCH5 in COS-7 cells promoted formation of aberrant, elongated mitochondria, and mitochondrial elongation could be prevented by coexpression of an MFN2 mutant lacking transmembrane domains. Expression of MARCH5 with mutations in the RING finger resulted in mitochondrial fragmentation and accumulation of punctate mitochondria in the perinuclear region. Immunoprecipitation analysis of transfected HeLa cells showed that MARCH5 bound endogenous MFN2 and DRP1, including ubiquitinated DRP1 species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 5 (MARCH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 5 (MARCH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 5 (MARCH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 5 (MARCH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 5 (MARCH5) ELISA Kit Customized Service Offer
  1. "MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology."EMBO Rep. 7:1019-1022(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins."J. Virol. 78:1109-1120(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics."EMBO J. 25:3618-3626(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division."J. Cell Biol. 178:71-84(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation."Mol. Biol. Cell 20:4524-4530(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."J. Cell Sci. 123:619-626(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]