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Transmembrane Protein 127 (TMEM127)

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Transmembrane Protein 127 (TMEM127)
CCC N121
HGNC 26038
MGI 1916720
PubMed 21156949
UniProt O75204
The TMEM127 protein contains 238 amino acids with 3 predicted transmembrane domains and shares 98.7% and 85.2% amino acid identity with mouse and zebrafish protein, respectively. Northern blot analysis of human tissues showed most abundant expression of 4.2-, 3.8-, and 3.1-kb transcripts in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, and colon.
TMEM127 expression was also found in a variety of epithelial cancer cell lines, including those derived from brain, breast, colon, prostate, and liver. Mouse Tmem127 showed ubiquitous expression in all mouse tissues examined at 1 month and 5 months of age. Immunoblot assay detected TMEM127 as a 26-kD band in transfected HEK293 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 127 (TMEM127) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 127 (TMEM127) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 127 (TMEM127) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 127 (TMEM127) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 127 (TMEM127) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 127 (TMEM127) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 127 (TMEM127) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 127 (TMEM127) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 127 (TMEM127) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 127 (TMEM127) ELISA Kit Customized Service Offer
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  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Germline mutations in TMEM127 confer susceptibility to pheochromocytoma."Nat. Genet. 42:229-233(2010) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas." JAMA 304:2611-2619(2010) [PubMed] [Europe PMC] [Abstract]