L-Antigen Family, Member 3 (LAGE3)

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ITBA2; CVG5; ESO3; DNA Segment On Chromosome X(Unique)9879 Expressed Sequence; EKC/KEOPS complex subunit LAGE3

L-Antigen Family, Member 3 (LAGE3)
LAGE3 belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. By searching EST databases with genomic sequences obtained from CpG islands located in the Xq28 region, Faranda et al. (1996) identified a gene, which they called ITBA2. The gene is relatively short, contains a 105-amino acid open reading frame, and is ubiquitously expressed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant L-Antigen Family, Member 3 (LAGE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for L-Antigen Family, Member 3 (LAGE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for L-Antigen Family, Member 3 (LAGE3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant L-Antigen Family, Member 3 (LAGE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for L-Antigen Family, Member 3 (LAGE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for L-Antigen Family, Member 3 (LAGE3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant L-Antigen Family, Member 3 (LAGE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to L-Antigen Family, Member 3 (LAGE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for L-Antigen Family, Member 3 (LAGE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for L-Antigen Family, Member 3 (LAGE3) ELISA Kit Customized Service Offer
  1. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach."Genomics 34:323-327(1996) [PubMed] [Europe PMC] [Abstract]
  4. "A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved."Gene 297:141-149(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME."PLoS ONE 7:E42822-E42822(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]