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PDZ Domain Containing Protein 7 (PDZD7)

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PDZK7

PDZ Domain Containing Protein 7 (PDZD7)
CCC N097
HGNC 26257
MGI 3608325
PubMed 20440071
RGD 1309882
UniProt Q9H5P4
Schneider et al. (2009) used positional cloning to identify the PDZD7 gene from junction fragments of a reciprocal t(10;11) translocation. They identified 4 PDZD7 isoform, of which the A and B isoforms contain 2 PDZ domains, whereas the shorter C and D contain no PDZ domains and 1 PDZ domain, respectively. RT-PCR analysis detected PDZD7 expression in human cortex with weak expression in the human inner ear.
By GST pull-down assay and Western blot analysis, Schneider et al. (2009) showed that PDZD7 interacted with SANS (USH1G) in HEK293T cells. GST pull-down assay in mouse retina showed that PDZD7 also interacted with harmonin (USH1C).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 7 (PDZD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 7 (PDZD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 7 (PDZD7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 7 (PDZD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 7 (PDZD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 7 (PDZD7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 7 (PDZD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 7 (PDZD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 7 (PDZD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 7 (PDZD7) ELISA Kit Customized Service Offer
  1. "PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome."J. Clin. Invest. 120:1812-1823(2010) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment."Hum. Mol. Genet. 18:655-666(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Solution structure of first PDZ domain of PDZ domain containing protein 7."Submitted (AUG-2007) to the PDB data bank