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Ras And EF-Hand Domain Containing Protein (RASEF)

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RAB45,Member RAS Oncogene Family; Ras-related protein Rab-45

Ras And EF-Hand Domain Containing Protein (RASEF)
CCC N082
HGNC 26464
MGI 2448565
PubMed 23686708
UniProt Q8IZ41
Wiki RASEF
By searching for genes in a region of chromosome 9q commonly deleted in acute myeloid leukemia (AML), followed by PCR of CD34-positive bone marrow cells, Sweetser et al. (2005) cloned RASEF. The deduced 844-amino acid protein contains a domain found in RAS (HRAS) family GTP-binding proteins.Sweetser et al. (2005) determined that the RASEF gene contains 17 exons.
Bone marrow biopsy revealed blasts and cells with maturing monocytic features. A final diagnosis of M5b AML was made. The authors reviewed the literature and concluded that leukemia may be the most likely diagnosis in a child with bilateral soft tissue orbital tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras And EF-Hand Domain Containing Protein (RASEF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras And EF-Hand Domain Containing Protein (RASEF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras And EF-Hand Domain Containing Protein (RASEF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras And EF-Hand Domain Containing Protein (RASEF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras And EF-Hand Domain Containing Protein (RASEF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras And EF-Hand Domain Containing Protein (RASEF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras And EF-Hand Domain Containing Protein (RASEF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras And EF-Hand Domain Containing Protein (RASEF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras And EF-Hand Domain Containing Protein (RASEF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras And EF-Hand Domain Containing Protein (RASEF) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mapping of a novel ocular and cutaneous malignant melanoma susceptibility locus to chromosome 9q21.32."J. Natl. Cancer Inst. 97:1377-1382(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase."Biochem. Biophys. Res. Commun. 357:661-667(2007) [PubMed] [Europe PMC] [Abstract]
  6. "EF-hand domain of human RASEF."Submitted (MAY-2007) to the PDB data bank
  7. "Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]