Von Willebrand Factor C And EGF Domains Protein (vWCE)

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URG11; VWC1; HBV X protein up-regulated gene 11 protein; HBxAg up-regulated gene 11 protein

Von Willebrand Factor C And EGF Domains Protein (vWCE)
URG11 expression is upregulated at the RNA and protein levels in the liver of HBV-infected individuals, but not in hepatocellular carcinomas from the same patients, or in uninfected individuals. In HepG2 cells, expression of HBxAg stimulated expression of URG11 by transcriptional transactivation, consistent with the hypothesis that URG11 is an effector of HBxAg. When expressed in HepG2 cells, both HBxAg and URG11 stimulated cell growth due to an increase in cell cycle progression and a decrease in cell death, in comparison to control cells. HBxAg and URG11 stimulated anchorage-independent growth in soft agar by 5- and 3-fold above background, respectively, and accelerated onset of tumor formation and size of tumors in Scid mice injected with HepG2 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Von Willebrand Factor C And EGF Domains Protein (vWCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Von Willebrand Factor C And EGF Domains Protein (vWCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Von Willebrand Factor C And EGF Domains Protein (vWCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Von Willebrand Factor C And EGF Domains Protein (vWCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Von Willebrand Factor C And EGF Domains Protein (vWCE) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis."Neoplasia 5:229-244(2003)
  4. "Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin."Hepatology 43:415-424(2006) [PubMed] [Europe PMC] [Abstract]