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Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27)

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Protrudin

Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27)
CCC N074
HGNC 26559
MGI 1919602
PubMed 16826525
RGD 735177
UniProt Q5T4F4
Transient transfection of HeLa cells with epitope-tagged ZFYVE27 constructs revealed that ZFYVE27 is predominantly expressed in punctate vesicles, although a tubular pattern of expression was observed in a small proportion of cells.
Colocalization studies detected overlapping expression with the endosomal marker EEA1 and the endoplasmic reticulum marker RTN1. Coimmunoprecipitation studies in NIH3T3 cells determined that spastin mediates interaction with ZFYVE27 through its N-terminal domain, which consists of an MIT (microtubule-interacting and trafficking) motif. An immunoprecipitation assay confirmed the interaction of endogenous spastin with ZFYVE27.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 27 (ZFYVE27) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Protrudin induces neurite formation by directional membrane trafficking."Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."Genes Cells 13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein."J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of the FYVE domain from human FYVE domain containing 27 isoform B protein."Submitted (NOV-2005) to the PDB data bank
  9. "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia."Am. J. Hum. Genet. 79:351-357(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The role of ZFYVE27/protrudin in hereditary spastic paraplegia."Am. J. Hum. Genet. 83:127-130(2008) [PubMed] [Europe PMC] [Abstract]