T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT)
[Edit]VSIG9; VSTM3; V-Set And Immunoglobulin Domain Containing 9; V-Set And Transmembrane Domain Containing 3
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TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
The predicted 244-amino acid TIGIT protein has a single Ig domain, followed by a type I transmembrane domain and a single intracellular immunoreceptor tyrosine-based inhibitory motif. It shares 88%, 67%, and 58% amino acid identity with its rhesus, dog, and mouse homologs, respectively.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPN056Mu01 | Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAN056Mu01 | Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | WB; IHC; ICC; IP. |
| LAN056Mu71 | Biotin-Linked Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPN056Ra01 | Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAN056Ra01 | Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
- "Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering."Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404(2012) [PubMed] [Europe PMC] [Abstract]