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Poly ADP Ribose Polymerase 15 (PARP15)

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pART7; ARTD7; BAL3; ADP-ribosyltransferase diphtheria toxin-like 7; B-aggressive lymphoma protein 3

Poly ADP Ribose Polymerase 15 (PARP15)
CCC N054
HGNC 26876
PubMed 18279766
UniProt Q460N3
PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity. By database analysis using PARP9 as query, followed by 5-prime and 3-prime RACE of normal mature B cells and primary diffuse large B-cell lymphoma cells, Aguiar et al. (2005) cloned PARP15, which they called BAL3.
The deduced 656-amino acid protein contains 2 N-terminal macrodomains and a C-terminal PARP domain. PARP15 mediated transcriptional repression, although at levels lower than that observed in PARP9, and the PARP15 macrodomains were required for repression. PARP15 recombinant protein displayed DNA-independent poly(ADP-ribose) polymerase catalytic activity.PARP15, PARP9, and PARP14 mapped in tandem within a 200-kb region on chromosome 3q21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly ADP Ribose Polymerase 15 (PARP15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly ADP Ribose Polymerase 15 (PARP15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly ADP Ribose Polymerase 15 (PARP15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly ADP Ribose Polymerase 15 (PARP15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly ADP Ribose Polymerase 15 (PARP15) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity."J. Biol. Chem. 280:33756-33765(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]