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Retinoid Inducible Nuclear Factor (RINF)

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CXXC5; WID; CXXC5; CF5; WT1-Induced Inhibitor Of Dishevelled; CXXC-type zinc finger protein 5; Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102

Retinoid Inducible Nuclear Factor (RINF)
CCC N045
HGNC 26943
MGI 1914643
PubMed 23988457
RGD 1359466
UniProt Q7LFL8
Using microarray analysis, Andersson et al. (2009) found that expression of Cxxc5 was significantly upregulated in rat neural stem cells following Bmp4 stimulation. In situ hybridization revealed that Cxxc5 expression localized selectively to Bmp4-rich dorsal telencephalon.
Cxxc5 was predominantly nuclear, but it also colocalized and interacted with several isoforms of the Wnt signaling intermediary Dvl (DVL1) in the cytoplasm. Cxxc5 influenced expression of the endogenous Wnt signaling target Axin2 and activated Wnt3a -induced reporter gene expression. Andersson et al. (2009) proposed that CXXC5 is a BMP-regulated modulator of Wnt signaling in telencephalic neural stem cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoid Inducible Nuclear Factor (RINF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoid Inducible Nuclear Factor (RINF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoid Inducible Nuclear Factor (RINF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoid Inducible Nuclear Factor (RINF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoid Inducible Nuclear Factor (RINF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoid Inducible Nuclear Factor (RINF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoid Inducible Nuclear Factor (RINF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoid Inducible Nuclear Factor (RINF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoid Inducible Nuclear Factor (RINF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoid Inducible Nuclear Factor (RINF) ELISA Kit Customized Service Offer
  1. "The CXXC finger 5 protein is required for DNA damage-induced p53 activation."Sci. China, Ser. C, Life Sci. 52:528-538(2009) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis."Blood 113:3172-3181(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2."Nucleic Acids Res. 41:2255-2266(2013) [PubMed] [Europe PMC] [Abstract]