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Fragile Site Associated Protein (FSA)

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Fragile Site Associated Protein (FSA)
CCC N044
HGNC 26953
MGI 2444631
PubMed 10470851
RGD 1309985
UniProt Q2LD37
Wiki KIAA1109
FSA is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. The deduced protein contains 1,957 amino acids. RT-PCR ELISA detected high expression in ovary and moderate expression in all other adult and fetal tissues examined. Within specific adult brain regions, highest expression was in amygdala, cerebellum, subthalamic nucleus, thalamus, and spinal cord.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fragile Site Associated Protein (FSA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fragile Site Associated Protein (FSA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fragile Site Associated Protein (FSA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fragile Site Associated Protein (FSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fragile Site Associated Protein (FSA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fragile Site Associated Protein (FSA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fragile Site Associated Protein (FSA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fragile Site Associated Protein (FSA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fragile Site Associated Protein (FSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fragile Site Associated Protein (FSA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fragile Site Associated Protein (FSA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fragile Site Associated Protein (FSA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fragile Site Associated Protein (FSA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fragile Site Associated Protein (FSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fragile Site Associated Protein (FSA) ELISA Kit Customized Service Offer
  1. "Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation."Gene 372:44-52(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21." Nat. Genet. 39:827-829(2007) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]