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INO80 Homolog (INO80)

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INOC1; INO80 Complex Subunit A; DNA helicase INO80; Putative DNA helicase INO80 complex homolog 1

INO80 Homolog (INO80)
CCC N043
HGNC 26956
MGI 1915392
PubMed 23524535
RGD 1310969
UniProt Q9ULG1
INOC1 is the human homolog of S. cerevisiae Ino80, the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INOC1 defines a subfamily of SWI2/SNF2 chromatin remodeling proteins.The deduced 1,556-amino acid INOC1 protein has a predicted molecular mass of 177 kD. The protein contains the conserved 7-motif SNF2 helicase domain, which is dispersed over 700 amino acids rather than the typical 400. It has a typical GxGK[S/T] sequence in SNF domain motif-1, a DEAQ, rather than a DExH/D, pattern in motif-2, and a 126-amino acid domain, termed DBINO (DNA-binding domain of INO80), that is conserved in members of the INO80 subfamily and is located upstream of the SNF2 helicase domain. INOC1 contains both N-terminal and C-terminal nuclear localization signals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant INO80 Homolog (INO80) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to INO80 Homolog (INO80) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to INO80 Homolog (INO80) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for INO80 Homolog (INO80) CLIA Kit Customized Service Offer
n/a ELISA Kit for INO80 Homolog (INO80) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant INO80 Homolog (INO80) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to INO80 Homolog (INO80) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to INO80 Homolog (INO80) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for INO80 Homolog (INO80) CLIA Kit Customized Service Offer
n/a ELISA Kit for INO80 Homolog (INO80) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant INO80 Homolog (INO80) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to INO80 Homolog (INO80) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to INO80 Homolog (INO80) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for INO80 Homolog (INO80) CLIA Kit Customized Service Offer
n/a ELISA Kit for INO80 Homolog (INO80) ELISA Kit Customized Service Offer
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  4. "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."J. Biol. Chem. 280:41207-41212(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity."Biochem. Biophys. Res. Commun. 339:313-320(2006) [PubMed] [Europe PMC] [Abstract]
  6. "YY1 functions with INO80 to activate transcription."Nat. Struct. Mol. Biol. 14:872-874(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner."Biochem. Biophys. Res. Commun. 402:619-625(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes."Biochem. J. 431:179-187(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability."Cell. Mol. Life Sci. 67:2283-2296(2010) [PubMed] [Europe PMC] [Abstract]
  15. "INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway."Proc. Natl. Acad. Sci. U.S.A. 107:17274-17279(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]