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UBX Domain Protein 2B (UBXN2B)

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p37; NSFL1 cofactor p37

UBX Domain Protein 2B (UBXN2B)
CCC N034
HGNC 27035
MGI 1915303
PubMed 23496005
RGD 1308557
UniProt Q14CS0
Rodent p37 formed a complex with p97 in cytosol and localized to Golgi and endoplasmic reticulum (ER). Small interfering RNA experiments in HeLa cells revealed that p37 was required for Golgi and ER biogenesis. Injection of anti-p37 antibodies into HeLa cells at different stages of the cell cycle showed that p37 was involved in Golgi and ER maintenance during interphase and in their reassembly at the end of mitosis.
In an in vitro Golgi reassembly assay, the p97/p37 complex showed membrane fusion activity that required p115-GM130 (GOLGA2) tethering and SNARE GS15 (BET1L). VCIP135 (VCPIP1) was also required, but its deubiquitinating activity was unnecessary for p97/p37-mediated activities.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 2B (UBXN2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 2B (UBXN2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 2B (UBXN2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 2B (UBXN2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 2B (UBXN2B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 2B (UBXN2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 2B (UBXN2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 2B (UBXN2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 2B (UBXN2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 2B (UBXN2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 2B (UBXN2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 2B (UBXN2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 2B (UBXN2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 2B (UBXN2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 2B (UBXN2B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis."Dev. Cell 11:803-816(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]