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Glucoside Xylosyltransferase 1 (GXYLT1)

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GLT8D3; Glycosyltransferase 8 Domain Containing 3

Glucoside Xylosyltransferase 1 (GXYLT1)
CCC N019
HGNC 27482
MGI 2684933
RGD 1563062
UniProt Q4G148
GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF) repeats of proteins such as NOTCH1.
The deduced 409-amino acid GXYLT1 protein contains a short N-terminal cytoplasmic domain, followed by a transmembrane domain, a stem region, and a large glycosyltransferase domain containing the conserved DxD motif. GXYLT1 and GXYLT2 share about 50% amino acid identity.HPLC analysis showed that the bond formed by GXYLT1 involved an alpha-1,3 linkage. GXYLT1 and GXYLT2 functioned as xylosyltransferases for the glucosylated peptide substrates EGF repeat 1 of factor VII (F7) and EGF repeats 1 through 5 of mouse Notch1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucoside Xylosyltransferase 1 (GXYLT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucoside Xylosyltransferase 1 (GXYLT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucoside Xylosyltransferase 1 (GXYLT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucoside Xylosyltransferase 1 (GXYLT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucoside Xylosyltransferase 1 (GXYLT1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of glycosyltransferase 8 family members as xylosyltransferases acting on o-glucosylated notch epidermal growth factor repeats."J. Biol. Chem. 285:1582-1586(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]