Ring Finger Protein 212 (RNF212)

[Edit]

ZHP3; Probable E3 SUMO-protein ligase RNF212

Ring Finger Protein 212 (RNF212)
Zhp3 knockout worms showed normal homolog pairing and synaptonemal complex formation. The timing of appearance and the nuclear localization of the recombination protein Rad51 seemed normal in these animals, suggesting proper initiation of meiotic recombination by DNA double-strand breaks.
However, the occurrence of univalents during diplotene indicated that C. elegans Zhp3 protein is essential for reciprocal recombination between homologous chromosomes and thus chiasma formation. In the absence of Zhp3, reciprocal recombination was abolished and double-strand breaks seemed to be repaired via alternative pathways, leading to achiasmatic chromosomes and the occurrence of univalents during meiosis I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 212 (RNF212) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 212 (RNF212) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 212 (RNF212) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 212 (RNF212) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 212 (RNF212) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 212 (RNF212) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 212 (RNF212) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 212 (RNF212) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 212 (RNF212) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 212 (RNF212) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence variants in the RNF212 gene associate with genome-wide recombination rate."Science 319:1398-1401(2008) [PubMed] [Europe PMC] [Abstract]