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Transmembrane Protease, Serine 11A (TMPRSS11A)

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ECRG1; HATL1; HESP; Airway trypsin-like protease 1; Epidermal type-II transmembrane serine protease; Esophageal cancer-susceptibility gene 1 protein

Transmembrane Protease, Serine 11A (TMPRSS11A)
CCC N012
HGNC 27954
MGI 2684853
UniProt Q6ZMR5
ECRG1 caused senescence-like changes in transfected mouse NIH3T3 cells, including changes in cell morphology, cell cycle arrest at the G1/S phase, and impaired cell proliferation. Transfected cells also stained positive for a cellular senescence marker. Telomerase activity was markedly decreased in ECRG1-expressing cells, and expression of p21 (CDKN1A) was increased.
The deduced 418-amino acid protein has characteristics of a membrane-anchored serine protease, including the his-asp-ser catalytic triad. RT-PCR and Northern blot analysis showed ECRG1 expression in normal esophagus, liver, colon, and lung, with downregulated expression in tumors, especially esophageal squamous cell carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protease, Serine 11A (TMPRSS11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protease, Serine 11A (TMPRSS11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protease, Serine 11A (TMPRSS11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protease, Serine 11A (TMPRSS11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protease, Serine 11A (TMPRSS11A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protease, Serine 11A (TMPRSS11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protease, Serine 11A (TMPRSS11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protease, Serine 11A (TMPRSS11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protease, Serine 11A (TMPRSS11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protease, Serine 11A (TMPRSS11A) ELISA Kit Customized Service Offer
  1. "Cloning and identification of cDNA fragments related to human esophageal cancer."Zhonghua Zhong Liu Za Zhi 20:254-257(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human and mouse proteases: a comparative genomic approach."Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1."J. Cell. Biochem. 92:65-76(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma."Carcinogenesis 27:798-802(2006) [PubMed] [Europe PMC] [Abstract]