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Membrane Associated Ring Finger Protein 2 (MARCH2)

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MARCH-II; RNF172; E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING-CH protein II; RING finger protein 172

Membrane Associated Ring Finger Protein 2 (MARCH2)
CCC N009
HGNC 28038
MGI 1925915
PubMed 11042152
RGD 1306395
UniProt Q9P0N8
Wiki MARCH2
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking.
MARCH2 shares about 60% identity with MARCH3 in the RING-CH and transmembrane domains. MARCH2 was expressed at variable levels in all tissues examined, with highest expression in heart. Immunofluorescence analysis revealed colocalization of epitope-tagged MARCH2 with an endoplasmic reticulum marker and with a lysosome marker.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 2 (MARCH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 2 (MARCH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 2 (MARCH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 2 (MARCH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 2 (MARCH2) ELISA Kit Customized Service Offer
  1. "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking."Mol. Biol. Cell 16:1696-1710(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins."J. Virol. 78:1109-1120(2004) [PubMed] [Europe PMC] [Abstract]
  6. "MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II."J. Biochem. 139:137-145(2006) [PubMed] [Europe PMC] [Abstract]