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GINS Complex Subunit 4 (GINS4)

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SLD5; DNA replication complex GINS protein SLD5

GINS Complex Subunit 4 (GINS4)
CCC M991
HGNC 28226
MGI 1923847
PubMed 20070258
RGD 1307397
UniProt Q9BRT9
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1), Psf2 (GINS2), and Psf3 (GINS3). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.
The deduced 223-amino acid protein contains an N-terminal coiled-coil domain, a central basic region, and a C-terminal domain that is conserved between the mouse and yeast proteins. RT-PCR of mouse tissues detected abundant expression in adult testis, and weak expression in thymus and bone marrow. No Sld5 was detected in brain, lung, liver, spleen, kidney, and heart. Immunohistochemical analysis detected Psf1 and Sld5 in the cytoplasm of transfected NIH3T3 mouse fibroblast.mouse Sld5 and Psf1 interacted in transfected NIH3T3 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 4 (GINS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 4 (GINS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 4 (GINS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 4 (GINS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 4 (GINS4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 4 (GINS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 4 (GINS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 4 (GINS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 4 (GINS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 4 (GINS4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 4 (GINS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 4 (GINS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 4 (GINS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 4 (GINS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 4 (GINS4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase."EMBO Rep. 8:99-103(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression."PLoS ONE 2:E594-E594(2007) [PubMed] [Europe PMC] [Abstract]
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  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular architecture of the human GINS complex."EMBO Rep. 8:678-684(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the human GINS complex."Genes Dev. 21:1316-1321(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of the human GINS complex and its assembly and functional interface in replication initiation."Nat. Struct. Mol. Biol. 14:388-396(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the GINS complex and functional insights into its role in DNA replication."Proc. Natl. Acad. Sci. U.S.A. 104:12685-12690(2007) [PubMed] [Europe PMC] [Abstract]