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BLM Associated Protein 18kDa (BLAP18)

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RMI2; C16orf75; RecQ-mediated genome instability protein 2

BLM Associated Protein 18kDa (BLAP18)
CCC M981
HGNC 28349
MGI 2685383
PubMed 18923083
UniProt Q96E14
RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability.The deduced 147-amino acid protein has a single oligonucleotide-binding (OB)-fold domain. RMI2 had an apparent molecular mass of 18 to 20 kD by SDS-PAGE. RMI2 orthologs were detected in vertebrates and plants, but not in lower organisms.
RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90%. Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BLM Associated Protein 18kDa (BLAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BLM Associated Protein 18kDa (BLAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BLM Associated Protein 18kDa (BLAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BLM Associated Protein 18kDa (BLAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for BLM Associated Protein 18kDa (BLAP18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BLM Associated Protein 18kDa (BLAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BLM Associated Protein 18kDa (BLAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BLM Associated Protein 18kDa (BLAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BLM Associated Protein 18kDa (BLAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for BLM Associated Protein 18kDa (BLAP18) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]
  5. "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]