≡

Coiled Coil Domain Containing Protein 86 (CCDC86)

[Edit]

CYCLON; Cytokine-induced protein with coiled-coil domain

Coiled Coil Domain Containing Protein 86 (CCDC86)
CCC M980
HGNC 28359
MGI 1277220
RGD 1359280
UniProt Q9H6F5
CCDC86 encodes a deduced 360-amino acid protein with a coiled-coil domain in the C terminus and repetitive sequences, which the authors referred to as SP repeats, near the N terminus. The SP repeats are shorter in the human and rat orthologs than in mice. The protein has 3 potential bipartite nuclear localization signals. Its promoter has redundant IL3-responsive elements, which were confirmed experimentally.
Ccdc86 expression was also detected in activated mouse peripheral CD4+ and CD8+ T cells. Immunoblots of HA-tagged human or mouse CCDC86 detected the protein in nuclear extracts. The nuclear localization was confirmed by microscopy, and the protein was shown to be phosphorylated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 86 (CCDC86) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 86 (CCDC86) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 86 (CCDC86) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 86 (CCDC86) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 86 (CCDC86) ELISA Kit Customized Service Offer
  1. "Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon."FEBS Lett. 581:975-980(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus."J. Biochem. Mol. Biol. 37:741-748(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]