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Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2)

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KMT5C; Lysine N-methyltransferase 5C; Histone-lysine N-methyltransferase SUV420H2

Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2)
CCC M970
HGNC 28405
MGI 2385262
PubMed 21357467
RGD 1305226
UniProt Q86Y97
SUV420H2 and the related enzyme SUV420H1 function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 on lysine-20 (K20). Accumulation of trimethylated histone H3K9 was unaffected. The deduced 468-amino acid protein contains a central SET domain and 3 additional regions that are conserved in Suv420h orthologs from other species. Fluorescence-tagged Suv420h2 localized to pericentric heterochromatin in transfected mouse embryonic fibroblasts (MEFs).the carcinogenic potential of human breast cancer cell lines correlated with loss of DNA methylation, which was accompanied by increased expression of maintenance DNA methyltransferase DNMT1 and the methyl-binding proteins MECP2 and MBD2, decreased trimethylation of H4K20, and hyperacetylation of histone H4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM970Mu01 Recombinant Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM970Mu01 Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) WB; IHC; ICC; IP.
LAM970Mu71 Biotin-Linked Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) WB; IHC; ICC.
LAM970Mu81 FITC-Linked Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]