Izumo Sperm Egg Fusion 1 (IZUMO1)
[Edit]OBF; Oocyte binding/fusion factor; Sperm-specific protein izumo
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The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.
Mass spectrometry, RT-PCR analysis of testis RNA, and database searching elucidated the DNA sequence and identified a human homolog . The predicted human gene encodes a 350-amino acid type I membrane protein of the Ig superfamily containing an extracellular Ig domain with a putative glycosylation site. Western blot analysis detected a 37-kD protein on the sperm surface after the exocytotic acrosome reaction process but not on fresh sperm. Anti-IZUMO, but not control, polyclonal antibody treatment inhibited fusion with zona pellucida-free hamster eggs.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Izumo Sperm Egg Fusion 1 (IZUMO1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Izumo Sperm Egg Fusion 1 (IZUMO1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Izumo Sperm Egg Fusion 1 (IZUMO1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Izumo Sperm Egg Fusion 1 (IZUMO1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Izumo Sperm Egg Fusion 1 (IZUMO1) | ELISA Kit Customized Service Offer |
- "The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs."Nature 434:234-238(2005) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure."Fertil. Steril. 90:1246-1248(2008) [PubMed] [Europe PMC] [Abstract]