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Pianissimo (PIA)

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RICTOR; AVO3; Rapamycin-Insensitive Companion Of Mammalian Target of Rapamycin; RPTOR Independent Companion Of MTOR,Complex 2

Pianissimo (PIA)
CCC M948
HGNC 28611
MGI 1926007
PubMed 15268862
RGD 1307224
UniProt Q6R327
Wiki RICTOR
RICTOR and MTOR (FRAP1) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. The deduced 1,708-amino acid protein has a calculated molecular mass of 192 kD. RICTOR contains evolutionarily conserved sequences, notably an N-terminal region of about 200 amino acids and several smaller regions, including a repeated block of 20 amino acids.Rapamycin treatment of human embryonic kidney cells eliminated the binding of MTOR to RAPTOR, but did not affect the interaction of MTOR with RICTOR. Knockdown of RICTOR caused accumulation of thick actin fibers throughout much of the cytoplasm in HeLa cells, loss of actin at the cell cortex, altered distribution of cytoskeletal proteins, and reduced protein kinase C (PKC)-alpha activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pianissimo (PIA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pianissimo (PIA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pianissimo (PIA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pianissimo (PIA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pianissimo (PIA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pianissimo (PIA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pianissimo (PIA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pianissimo (PIA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pianissimo (PIA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pianissimo (PIA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pianissimo (PIA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pianissimo (PIA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pianissimo (PIA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pianissimo (PIA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pianissimo (PIA) ELISA Kit Customized Service Offer
  1. "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton."Curr. Biol. 14:1296-1302(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract].
  6. "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive."Nat. Cell Biol. 6:1122-1128(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex."Science 307:1098-1101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of Protor as a novel Rictor-binding component of mTOR complex-2."Biochem. J. 405:513-522(2007) [PubMed] [Europe PMC] [Abstract]
  10. "PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling."J. Biol. Chem. 282:25604-25612(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling."Mol. Cell. Biol. 30:908-921(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex."Hum. Mol. Genet. 22:4031-4042(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains."PLoS ONE 8:E65586-E65586(2013) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]