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Ptip Associated Protein 1 (PA1)

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GAS; C16orf53; PAGR1; Glutamate-Rich Coactivator Interacting With SRC1/NCOA1; PAXIP1-associated glutamate-rich protein 1

Ptip Associated Protein 1 (PA1)
CCC M940
HGNC 28707
MGI 1914528
PubMed 24260416
UniProt Q9BTK6
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex .By affinity purification of PTIP (PAXIP1)-associated proteins in a HeLa cell line expressing mouse Ptip, followed by mass spectrometry, Cho et al. (2007) identified C16ORF53, which they designated PA1.
The predicted 254-amino acid protein shares 87% sequence identity with the mouse ortholog. When ectopically expressed in HeLa cells, PA1 localized to the nucleus.The protein complex is a Set1-like histone methyltransferase complex that displays histone H3 lysine-4 (H3K4) methyltransferase activity. GST pull-down assays showed that PA1 interacts directly with PTIP but not with ASH2L, RBBP5, WDR5, or NCOA6. PA1 requires PTIP for interaction with the rest of the complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ptip Associated Protein 1 (PA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ptip Associated Protein 1 (PA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ptip Associated Protein 1 (PA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ptip Associated Protein 1 (PA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ptip Associated Protein 1 (PA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ptip Associated Protein 1 (PA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ptip Associated Protein 1 (PA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ptip Associated Protein 1 (PA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ptip Associated Protein 1 (PA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ptip Associated Protein 1 (PA1) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]