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TATA Box Binding Protein Associated Factor 1D (TAF1D)

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JOSD3; TAF(I)41; TAFI41; Josephin Domain Containing 3; Transcription initiation factor SL1/TIF-IB subunit D; RNA polymerase I-specific TBP-associated factor 41 kDa

TATA Box Binding Protein Associated Factor 1D (TAF1D)
CCC M934
HGNC 28759
MGI 1922566
RGD 1309627
UniProt Q9H5J8
TAF1D is a member of the SL1 complex, which includes TBP and TAF1A, TAF1B, and TAF1C, and plays a role in RNA polymerase I transcription. The 278-amino acid protein contains a bipartite nuclear targeting motif and a number of putative phosphorylation sites.
GFP-tagged TAF1D colocalized to the nucleus with POLB. PCR and Western blot analysis detected TAF1D expression in ovarian tumors but not in normal ovarian tissues.TAF1D is 41-kD subunit of the SL1 complex and plays a role in RNA polymerase I transcription. Reduction of TAF1D by siRNA decreased RNA polymerase I transcription and reduced rRNA promoter occupancy of the SL1 complex and RNA polymerase I. TAF1D may act as a coactivator in UBF-activated transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TATA Box Binding Protein Associated Factor 1D (TAF1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TATA Box Binding Protein Associated Factor 1D (TAF1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TATA Box Binding Protein Associated Factor 1D (TAF1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TATA Box Binding Protein Associated Factor 1D (TAF1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Box Binding Protein Associated Factor 1D (TAF1D) ELISA Kit Customized Service Offer
  1. "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype."Cancer Res. 64:7673-7677(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
  5. "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription."EMBO J. 26:1560-1568(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]