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Ischemia/Reperfusion Inducible Protein (IRIP)

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YRDC; SUA5; DRIP3; YrdC domain-containing protein, mitochondrial; Dopamine receptor-interacting protein 3

Ischemia/Reperfusion Inducible Protein (IRIP)
CCC M922
HGNC 28905
MGI 2387201
PubMed 16024787
RGD 708492
UniProt Q86U90
YRDC shares 90% amino acid identity with its mouse ortholog and is highly conserved over its SUA5-YCIO-YRDC domain from E. coli to human. Northern blot analysis detected a 2.5-kb transcript in all human tissues examined with highest expression in liver, brain, and pancreas.YRDC transfection and overexpression resulted in decreased 1-methyl-4-phenylpyridinium (MPP+) transport, and a YRDC-mutant protein resulted in increased MPP+ transport. Inhibition of YRDC by short interfering RNA in HeLa cells resulted in increased MPP+ transport, and YRDC overexpression decreased MPP+ transport mediated by organic cation transporters OCT2 (SLC22A2) and OCT3 (SLC22A3), as well as by organic anion transporter OAT1 (SLC22A6) and monoamine transporters DAT (SLC6A3), NET (SLC6A2), and SERT (SLC6A4).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ischemia/Reperfusion Inducible Protein (IRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ischemia/Reperfusion Inducible Protein (IRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ischemia/Reperfusion Inducible Protein (IRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ischemia/Reperfusion Inducible Protein (IRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ischemia/Reperfusion Inducible Protein (IRIP) ELISA Kit Customized Service Offer
  1. "Isolation and identification of a novel cDNA that encodes human yrdC protein."J. Hum. Genet. 48:164-169(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity."Mol. Cell. Biol. 25:6496-6508(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]