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Family With Sequence Similarity 175, Member B (FAM175B)

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ABRO1; Abraxas Brother; BRISC complex subunit Abro1

Family With Sequence Similarity 175, Member B (FAM175B)
CCC M907
HGNC 28975
MGI 1926116
PubMed 8590280
RGD 1308918
UniProt Q15018
Wiki KIAA0157
In a bioinformatics analysis to reveal proteins related to Abraxas (ABRA1), Wang et al. (2007) identified the KIAA0157 protein (Nagase et al., 1995). The 415-amino acid protein, which Wang et al. (2007) designated ABRO1 for 'Abraxas brother-1,' shares 39% identity to ABRA1 in the N-terminal two-thirds of the protein (amino acids 1 to 260), including a coiled-coil domain and a region called the ABR domain. However, ABRO1 lacks the phosphorylated ser-X-X-phe motif of ABRA1 and, unlike ABRA1, does not bind to BRCA1 .
By PCR of a panel of human-rodent hybrid cell lines, Nagase et al. (1995) mapped the FAM175B gene to chromosome 10.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member B (FAM175B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member B (FAM175B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member B (FAM175B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member B (FAM175B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member B (FAM175B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member B (FAM175B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member B (FAM175B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member B (FAM175B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member B (FAM175B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member B (FAM175B) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response."Science 316:1194-1198(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."EMBO J. 28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
  9. "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."Genes Dev. 23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]