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Family With Sequence Similarity 38, Member A (FAM38A)

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PIEZO1; Mib; Piezo-type mechanosensitive Ion channel component 1; Membrane protein Induced by Beta-amyloid treatment

Family With Sequence Similarity 38, Member A (FAM38A)
CCC M904
HGNC 28993
MGI 3603204
PubMed 22529292
UniProt Q92508
The deduced 2,090-amino acid human FAM38A protein contains a signal sequence, 24 transmembrane domains, and shares 83.1% amino acid identity with rat Fam38a. Northern blot analysis detected moderate expression of rat Fam38a in lung and kidney, and weak expression in heart, spleen, and liver. Double immunofluorescence studies colocalized rat Fam38a with Serca2 (ATP2A2) and beta-COP (COPB), markers for the endoplasmic reticulum (ER) and ER-Golgi intermediate compartment, respectively. In situ hybridization analysis of human brain sections detected FAM38A expression in neurons but not in quiescent astrocytes. In contrast, brain sections from Alzheimer disease (AD) patients displayed FAM38A expression in approximately half of the activated astrocytes located around classic senile plaques.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 38, Member A (FAM38A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 38, Member A (FAM38A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 38, Member A (FAM38A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 38, Member A (FAM38A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 38, Member A (FAM38A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 38, Member A (FAM38A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 38, Member A (FAM38A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 38, Member A (FAM38A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 38, Member A (FAM38A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 38, Member A (FAM38A) ELISA Kit Customized Service Offer
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  2. "A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes."Brain Res. 1108:19-27(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis."Blood 120:1908-1915(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum."J. Cell Sci. 123:51-61(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Piezo1 integration of vascular architecture with physiological force." Nature 515:279-282(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1." Blood 121:3925-3935(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels."Nat. Commun. 4:1884-1884(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1."Proc. Natl. Acad. Sci. U.S.A. 110:E1162-1168(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report."Blood Cells Mol. Dis. 52:53-54(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Recurrent mutation in the PIEZO1 gene in two families of hereditary xerocytosis with fetal hydrops."Clin. Genet. 85:293-295(2014) [PubMed] [Europe PMC] [Abstract]