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NLR Family, CARD Domain Containing Protein 5 (NLRC5)

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NOD27; CLR16.1; NOD4; Caterpiller protein 16.1; Nucleotide-Binding Oligomerization Domain,Leucine Rich Repeat And CARD Domain Containing 5; NOD-Like Receptor C5

NLR Family, CARD Domain Containing Protein 5 (NLRC5)
CCC M895
HGNC 29933
MGI 3612191
PubMed 20434986
UniProt Q86WI3
Wiki NLRC5
NLRC5 is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.NLRC5 is an IFN-γ–inducible nuclear protein, and the expression of NLRC5 resulted in enhanced MHC class I expression in lymphoid as well as epithelial cell lines. NLRC5 associates with and activates the promoters of MHC class I genes. The IFN-γ–induced up-regulation of MHC class I requires NLRC5, because knockdown of NLRC5 specifically impaired the expression of MHC class I. In addition to MHC class I genes, NLRC5 also induced the expression of β2-microglobulin, transporter associated with antigen processing, and large multifunctional protease, which are essential for MHC class I antigen presentation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM895Hu01 Recombinant NLR Family, CARD Domain Containing Protein 5 (NLRC5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to NLR Family, CARD Domain Containing Protein 5 (NLRC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, CARD Domain Containing Protein 5 (NLRC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, CARD Domain Containing Protein 5 (NLRC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, CARD Domain Containing Protein 5 (NLRC5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, CARD Domain Containing Protein 5 (NLRC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, CARD Domain Containing Protein 5 (NLRC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, CARD Domain Containing Protein 5 (NLRC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, CARD Domain Containing Protein 5 (NLRC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, CARD Domain Containing Protein 5 (NLRC5) ELISA Kit Customized Service Offer
  1. "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product."Biochem. Biophys. Res. Commun. 302:575-580(2003) [PubMed] [Europe PMC] [Abstract]
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  3. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways."Cell 141:483-496(2010) [PubMed] [Europe PMC] [Abstract]
  7. "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses."J. Immunol. 184:1990-2000(2010) [PubMed] [Europe PMC] [Abstract]
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  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]