Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1)
[Edit]UNR; NRU; Upstream of NRAS; N-ras upstream gene protein
RNase protection assays showed that this gene, termed UNR by them, is transcribed in the same direction as NRAS and that its 3-prime end is located only 130 bp from the transcription initiation site of NRAS. The close spatial relationship was conserved in all species from which the NRAS gene had been isolated. The UNR cDNA contained an open reading frame capable of encoding a protein of 798 amino acids. UNR transcripts were detected in mouse, rat, and human cells. Only a single copy of UNR was detected in the mouse. The gene produced multiple transcripts that differed in their 3-prime ends and apparently resulted from the differential use of multiple polyadenylation sites located in the 3-prime untranslated region of the gene. Both UNR and NRAS were expressed in all tissues examined and the 2 genes may be coordinately regulated.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPM893Hu01 | Recombinant Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAM893Hu01 | Polyclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | WB; IHC; ICC; IP. |
MAM893Hu21 | Monoclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | WB; IHC; ICC; IP. | |
Assay Kits | SEM893Hu | ELISA Kit for Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) | ELISA Kit Customized Service Offer |
- "Organization of the human N-ras locus: characterization of a gene located immediately upstream of N-ras."Oncogene 6:721-730(1991) [PubMed] [Europe PMC] [Abstract]
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU)."Biochim. Biophys. Acta 1172:64-72(1993) [PubMed] [Europe PMC] [Abstract]
- "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA."Genes Dev. 13:437-448(1999) [PubMed] [Europe PMC] [Abstract]
- "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex."Cell 103:29-40(2000) [PubMed] [Europe PMC] [Abstract]
- "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant."Genes Dev. 18:2010-2023(2004) [PubMed] [Europe PMC] [Abstract]
- "The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex."Nucleic Acids Res. 33:7074-7089(2005) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
- "The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein."J. Struct. Funct. Genomics 11:181-188(2010) [PubMed] [Europe PMC] [Abstract]