NMDA Receptor Regulated 2 (NARG2)

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ICE2; BRCC1; Breast Cancer Cell 1; Interactor of little elongator complex ELL subunit 2; Little elongation complex subunit 2

NMDA Receptor Regulated 2 (NARG2)
The deduced full-length 988-amino acid protein has repeats of (S/T)Pxx, which is a putative DNA-binding domain, and it has a putative nuclear localization signal near the C terminus. The deduced 982-amino acid protein shares 74% identity with mouse Narg2. No NARG2 orthologs were found in yeast, nematode, fly, or fish databases. Northern blot analysis of human tissues detected significant NARG2 expression in fetal kidney, liver, lung, and brain, and in adult testis, but little or no expression in the adult counterparts or in other adult tissues examined. Epitope-tagged mouse Narg2 localized to the nucleus of transfected rat kidney fibroblasts.Narg2 expression was downregulated following retinoic acid-induced neuronal differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NMDA Receptor Regulated 2 (NARG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NMDA Receptor Regulated 2 (NARG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NMDA Receptor Regulated 2 (NARG2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NMDA Receptor Regulated 2 (NARG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NMDA Receptor Regulated 2 (NARG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NMDA Receptor Regulated 2 (NARG2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NMDA Receptor Regulated 2 (NARG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NMDA Receptor Regulated 2 (NARG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NMDA Receptor Regulated 2 (NARG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NMDA Receptor Regulated 2 (NARG2) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development."Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The little elongation complex regulates small nuclear RNA transcription."Mol. Cell 44:954-965(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The little elongation complex functions at initiation and elongation phases of snRNA gene transcription."Mol. Cell 51:493-505(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]