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F-Box Protein 40 (FBXO40)

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Fbx40; Muscle disease-related protein; F-box only protein 40

F-Box Protein 40 (FBXO40)
CCC M883
HGNC 29816
MGI 2443753
PubMed 22033112
RGD 1309781
UniProt Q9UH90
Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin , and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
The 3-prime UTR of the transcript contains several repetitive elements, and the deduced protein contains 717 amino acids. RT-PCR ELISA detected highest expression in skeletal muscle, followed by fetal brain, adult heart, brain, and amygdala. Low expression was detected in ovary and thalamus, and little to no expression was detected in all other tissues and specific brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 40 (FBXO40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 40 (FBXO40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 40 (FBXO40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 40 (FBXO40) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 40 (FBXO40) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 40 (FBXO40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 40 (FBXO40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 40 (FBXO40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 40 (FBXO40) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 40 (FBXO40) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 40 (FBXO40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 40 (FBXO40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 40 (FBXO40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 40 (FBXO40) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 40 (FBXO40) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy."Gene 404:53-60(2007) [PubMed] [Europe PMC] [Abstract]