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Cytosolic Thiouridylase Subunit 1 (CTU1)

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ATPBD3; NCS6; ATP Binding Domain 3; ATP-binding domain-containing 3; Cancer-associated gene; Cytoplasmic tRNA 2-thiolation 1; Cytoplasmic tRNA adenylyltransferase 1

Cytosolic Thiouridylase Subunit 1 (CTU1)
CCC M862
HGNC 29590
MGI 2385277
PubMed 19337729
RGD 1308740
UniProt Q7Z7A3
By sequencing proteins that interacted with URM1, followed by database analysis and PCR of a HeLa cell cDNA library, Schlieker et al. (2008) cloned ATPBD3. Endogenous ATPBD3 migrated at an apparent molecular mass of 38 kD by SDS-PAGE. Schlieker et al. (2008) showed that human ATPBD3 thiolated uracils on tRNAs with URM1 functioning as the sulfur carrier intermediate. Knockdown of either URM1 or ATPBD3 in HeLa cells reduced thiolation of uracil in the anticodon region of tRNA-lys(UUU) .
Hartz (2009) mapped the ATPBD3 gene to chromosome 19q13.33 based on an alignment of the ATPBD3 sequence with the genomic sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Thiouridylase Subunit 1 (CTU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Thiouridylase Subunit 1 (CTU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Thiouridylase Subunit 1 (CTU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Thiouridylase Subunit 1 (CTU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Thiouridylase Subunit 1 (CTU1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway."Proc. Natl. Acad. Sci. U.S.A. 105:18255-18260(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]